You can please some of the people all of the time

I am reminded today of the famous words from poet John Lydgate, later adapted by President Lincoln - and appearing in various permutations:
“You can please some of the people all of the time, you can please all of the people some of the time, but you can’t please all of the people all of the time”.
Life seems to be a lot like that all the time.  So what do we do? Please some people all the time or all people some of the time? What happens if we try to please everyone all the time?
How about ourselves, were do we fall in that saying? I don't know, but I suppose it is important to make ourselves happy once in awhile.